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Objective: According to the neurodevelopmental model, schizophrenia is a developmental disorder that begins to occur during the brain development. Factors that cause developmental disorder in the brain are unclear. As a result of prenatal androgen exposure, the ratio of the second to fourth fingers (2D:4D) changes and it has been studied for many diseases. In this study, we aimed to examine 2D:4D ratio and the ratio of the length of the forearm and hand in patients with schizophrenia and its difference with golden ratio and by comparing with the control group.
Methods: The study was consisted of 103 patients with schizophrenia, who were hospitalized at a university hospital and a healthy control of 100 subjects. Finger, hand and forearm measurements was made and compared with healthy controls and golden ratio.
Results: Right 2D:4D ratio was measured as 0.9717 in the patient group and 0.9595 in the control group. The difference between the two groups was statistically significant (p= 0.018). The right forearm: right hand ratio was 1.3815 for the patients, while it was measured as 1.4146 in the control group. The difference between the two groups was also statistically significant (p= 0.004).
Conclusions: There has not been much work on this issue about the golden ratio. Our findings were compatible with those of the earlier studies and support the neurodevelopmental hypothesis.